LISA consists of three spacecraft that monitor their mutual distance with laser beams. When that distance starts fluctuating, the detector knows a gravitational wave is passing through. LISA will be sensitive enough to even notice fluctuations as small as an atomic nucleus at certain wavelengths. This is necessary because the currently undetected supermassive black holes are billions of lightyears away, so their gravitational waves are attenuated as they arrive in our Solar System.

LISA will be chasing Earth in its orbit around the Sun, more than fifty million kilometers behind. With its arms of 2.5 millions kilometers, LISA will be able to measure waves with much longer wavelengths than the ground-based detectors such as LIGO and Virgo. This allows it to listen to supermassive black holes of millions of solar masses orbiting around each other, producing long wavelengths. LIGO and Virgo are only sensitive to collisions between stellar black holes and neutron stars at a mere distance of tens of millions of lightyears, because the corresponding short wavelengths match their relatively short detector arms. Also waves from the deep Universe have long wavelengths, such as those from the chaotic epoch right after the Big Bang and from the first seeds of supermassive black holes.